Natural killer frequency determines natural killer cytotoxicity directly in accentuated zones and indirectly in “moderate-to-normal frequency” segment
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چکیده
منابع مشابه
THE CYTOTOXICITY PATHWAY OF NATURAL KILLER CELLS IN CORD BLOOD COMPARED TO P ERIPHERAL BLOOD
The cytotoxic activity of natural killer cells is usually tested by radioactive assay CSI Cr release assay), which detects the release of cytoplasmic contents after plasma membrane disintegration of dying cells. In contrast to this indirect evaluation of cytotoxicity, the assessment of cell damage by flow cytometry aims to provide a more exact characterization of the death pathway via detec...
متن کاملIncreased Natural Killer Cells Activity in Schizophrenic Patients
Background: Schizophrenia has been associated with altered immunity. Different studies regarding natural killer cell activity (NKA) in schizophrenic patients have shown inconsistent results. Objectives: To evaluate NK cell activity in schizophrenic patients in comparison with healthy control individuals. Methods: 30 medication-free schizophrenic patients and 41 healthy sex, age and smoking st...
متن کاملFrequency and phenotype of natural killer cells and natural killer cell subsets in bovine lymphoid compartments and blood
Natural killer (NK) cells are widely distributed in lymphoid and non-lymphoid tissues, but little is known about the recirculation of NK cells between blood and tissues. This is relevant to understanding recirculation in the steady-state and also for determining the roles for NK cells in vaccine-induced immunity and responses to infection. Therefore, the percentage of NK cells and their phenoty...
متن کاملCystatin F Affects Natural Killer Cell Cytotoxicity
Cystatin F is a cysteine peptidase inhibitor which, unlike other cystatin family members, is targeted to endosomal/lysosomal compartments. It is synthesized as an inactive disulfide-linked dimer which is then converted to an active monomer by proteolytic cleavage of 15 N-terminal residues. Cystatin F has been suggested to regulate the cytotoxicity of natural killer (NK) cells by inhibiting the ...
متن کاملRepeated cupping manipulation temporary decreases natural killer lymphocyte frequency, activity and cytotoxicity.
OBJECTIVE Elevated natural killer lymphocyte cytotoxicity (NKc) has been linked with reproductive problems in women. Here we evaluate the potential benefit of cupping therapy (CT) in reproduction-related immune responses. METHODS This was a pilot clinical study. Participants were healthy female volunteers (n = 23) with elevated NKc, and received repeated CT 3 times over 5 d (inner pressure 40...
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ژورنال
عنوان ژورنال: Central European Journal of Immunology
سال: 2020
ISSN: 1426-3912
DOI: 10.5114/ceji.2020.101263